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immune checkpoint inhibitors (icis)  (Innovative Therapies)

 
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    Innovative Therapies immune checkpoint inhibitors (icis)
    Immune Checkpoint Inhibitors (Icis), supplied by Innovative Therapies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/immune+checkpoint+inhibitors+(icis)/immune+checkpoint+inhibitors/pm39941108-30-17-12
    Average 90 stars, based on 1 article reviews
    immune checkpoint inhibitors (icis) - by Bioz Stars, 2026-10
    90/100 stars

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    Article Title: Clinical features affecting survival in metastatic NSCLC treated with immunotherapy: A critical review of published data.
    Article Snippet: Immune checkpoint inhibitors (ICIs) represent one of the main steps forward for the treatment of advanced or metastatic non-small-cell lung cancer (NSCLC), without oncogenic driver alterations.. Despite this recent progress, only a minority of patients achieve a broad and durable benefit and another proportion report poor survival and sometimes fast disease progression, confirming the need to optimise the patient’s selection.. To date, several issues are unsolved about how to personalise the immunotherapy treatment for individual patients.

    Article Title: Efficacy and safety of programmed cell-death-protein-1 and its ligand inhibitors in pretreated patients with epidermal growth-factor receptor-mutated or anaplastic lymphoma kinase-translocated lung adenocarcinoma
    Article Snippet: [ ] As a consequence, the management of patients with locally advanced or metastatic NSCLCs has been improved with innovative therapies, such as immune-checkpoint inhibitors (ICIs) and, for patients with oncogenic drivers, targeted tyrosine-kinase inhibitors (TKIs).

    Article Title: Optimized patient-specific immune checkpoint inhibitors therapy for cancer treatment based on tumor immune microenvironment modeling
    Article Snippet: Immune checkpoint inhibitors (ICIs) have significantly advanced the treatment of various cancers, including lung cancer, melanoma, and head and neck cancers., These innovative therapies target the immune checkpoints (ICs), cellular mechanisms that tumor cells exploit to suppress the activity of activated T cells and thus evade immune surveillance.

    Article Title: Combining antibody-drug conjugates with immunotherapy in solid tumors: current landscape and future perspectives.
    Article Snippet: Antibody-drug conjugates (ADCs) and immunotherapy have prompted a revolution in the treatment of cancer.. However, only a limited fraction of patients obtained a long-term benefit; consequently, combination studies have become a central focus of the current preclinical and clinical research in oncology.. A strong biological rationale supports the investigation of combining ADCs with immunotherapy to overcome the occurrence of resistance and improve patient outcomes.

    Article Title: Optimizing rWTC-MBTA Vaccine Formulations, Dosing Regimens, and Cryopreservation Techniques to Enhance Anti-Metastatic Immunotherapy.
    Article Snippet: Immunotherapy has emerged as a leading approach to cancer treatment, with several innovative therapies, such as immune checkpoint inhibitors (ICIs), oncolytic viruses, and chimeric antigen receptor T-cell therapies (CAR-Ts), recently receiving clinical approval [12–16].



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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
    Anti Mouse Immune Checkpoint Inhibitor Ici Antibodies For αctla4, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and <t>αCTLA4.</t> Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).
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    Image Search Results


    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and αCTLA4. Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).

    Journal: iScience

    Article Title: Combined prostate cancer vaccine plus immune checkpoint inhibition synergizes to eliminate prostate cancer

    doi: 10.1016/j.isci.2025.114552

    Figure Lengend Snippet: Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and αCTLA4. Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).

    Article Snippet: Anti-mouse immune checkpoint inhibitor (ICI) antibodies for αCTLA4 (Cat. #BP0164; Clone #9D9) and αPD1 (Cat. #BP0146; Clone # RMP1-14) were purchased from BioXcell (Lebanon, NH, USA).

    Techniques: Drug discovery, Comparison, Control

    Therapeutic efficacy of the Ad-PS2 vaccine combined with different doses of αCTLA4 (A) Overall measurement of tumor growth in mice injected with 100 or 200 μg of αCTLA in combination with the Ad-PS2 vaccine; (B) tumor growth curve for individual mouse receiving 100 μg of αCTLA ± Ad-PS2 and control groups pooled from two independent experiments ( n is the number of mice), and (C) rechallenging of tumor-free mice treated with the Ad-PS2 vaccine combined with αCTLA4 from two sets of experiments ( n = 9). Data are represented as mean ± SEM.

    Journal: iScience

    Article Title: Combined prostate cancer vaccine plus immune checkpoint inhibition synergizes to eliminate prostate cancer

    doi: 10.1016/j.isci.2025.114552

    Figure Lengend Snippet: Therapeutic efficacy of the Ad-PS2 vaccine combined with different doses of αCTLA4 (A) Overall measurement of tumor growth in mice injected with 100 or 200 μg of αCTLA in combination with the Ad-PS2 vaccine; (B) tumor growth curve for individual mouse receiving 100 μg of αCTLA ± Ad-PS2 and control groups pooled from two independent experiments ( n is the number of mice), and (C) rechallenging of tumor-free mice treated with the Ad-PS2 vaccine combined with αCTLA4 from two sets of experiments ( n = 9). Data are represented as mean ± SEM.

    Article Snippet: Anti-mouse immune checkpoint inhibitor (ICI) antibodies for αCTLA4 (Cat. #BP0164; Clone #9D9) and αPD1 (Cat. #BP0146; Clone # RMP1-14) were purchased from BioXcell (Lebanon, NH, USA).

    Techniques: Drug discovery, Injection, Control

    Preclinical evaluation of the toxic profile of the Ad-PS2 vaccine combined with αCTLA4 therapy (A) Scatterplot of the counted inflammatory cells in the liver (3 different fields at 40x) between age-matched naive mice and vaccine-treated groups of mice ( n = 3) based on histopathology studies, and (B) liver panel analytes measured in serum among the naive ( n = 3), Ad-LacZ control ( n = 5), Ad-PS2 vaccine ( n = 7), and Ad-PS2 + αCTLA4 ( n = 3) groups of mice. Data are shown as mean ± SEM with a significant difference (∗ p < 0.05) and ns = non-significant following a nonparametric Kruskal-Wallis test.

    Journal: iScience

    Article Title: Combined prostate cancer vaccine plus immune checkpoint inhibition synergizes to eliminate prostate cancer

    doi: 10.1016/j.isci.2025.114552

    Figure Lengend Snippet: Preclinical evaluation of the toxic profile of the Ad-PS2 vaccine combined with αCTLA4 therapy (A) Scatterplot of the counted inflammatory cells in the liver (3 different fields at 40x) between age-matched naive mice and vaccine-treated groups of mice ( n = 3) based on histopathology studies, and (B) liver panel analytes measured in serum among the naive ( n = 3), Ad-LacZ control ( n = 5), Ad-PS2 vaccine ( n = 7), and Ad-PS2 + αCTLA4 ( n = 3) groups of mice. Data are shown as mean ± SEM with a significant difference (∗ p < 0.05) and ns = non-significant following a nonparametric Kruskal-Wallis test.

    Article Snippet: Anti-mouse immune checkpoint inhibitor (ICI) antibodies for αCTLA4 (Cat. #BP0164; Clone #9D9) and αPD1 (Cat. #BP0146; Clone # RMP1-14) were purchased from BioXcell (Lebanon, NH, USA).

    Techniques: Histopathology, Control